Dietary accumulation and sustained hepatic mixed function oxidase enzyme induction by 2,3,4,7,8‐pentachlorodibenzofuran in rainbow trout
Identifieur interne : 001763 ( Main/Exploration ); précédent : 001762; suivant : 001764Dietary accumulation and sustained hepatic mixed function oxidase enzyme induction by 2,3,4,7,8‐pentachlorodibenzofuran in rainbow trout
Auteurs : Derek Muir [Canada] ; Alvin L. Yarechewski [Canada] ; Donald A. Metner [Canada] ; W. Lyle Lockhart [Canada] ; G. R. Barrie Webster [Canada] ; Kenneth J. Friesen [Canada]Source :
- Environmental Toxicology and Chemistry [ 0730-7268 ] ; 1990-12.
Descripteurs français
- Wicri :
- topic : Poisson.
English descriptors
Abstract
Accumulation of and hepatic monooxygenase induction by 2,3,4,7,8‐pentachlorodibenzofuran (PnCDF) were studied in juvenile rainbow trout (Onchorhynchus mykiss) by feeding treated food for 31 d followed by a 180 d depuration period. Efficiency of assimilation was 44 and 41% at exposure concentrations of 9.0 and 0.82 ng g−1 PnCDF, respectively. Depuration of PnCDF followed first‐order kinetics with half‐lives (based on toluene extraction of 14C‐radiolabel corrected for growth dilution) of 61 and 69 d at the low and high exposure concentrations, respectively. Monooxygenase enzyme induction measured by ethoxyresorufin‐O‐deethylase (EROD) activity in individual trout livers was 84‐ and four‐fold higher after 31 d of exposure to 9.0 and 0.82 ng g−1, respectively, than in livers of unexposed fish. Sustained EROD activity at the high treatment concentrations was observed during the 180 d depuration phase. Ethoxyresorufin‐O‐deethylase activity declined at approximately half the rate of elimination of PnCDF. No significant differences between growth rates of treated and control fish were found.
Url:
DOI: 10.1002/etc.5620091205
Affiliations:
- Canada
- Manitoba, Ontario
- Burlington (Ontario), Winnipeg
- Centre canadien des eaux intérieures, Université du Manitoba
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Le document en format XML
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